Program

13:00-14:00 Welcome and Registration, poster setup/poster viewing open 

14:00-14:15 Official opening and introduction by Pernette Verschure, NL 

Session 1: Epigenetic regulatory mechanisms: 'State-of-the-art epigenetics' 

Session chairs: Pernette Verschure (University of Amsterdam, NL), and Antoine van Kampen/Perry Moerland (University of Amsterdam, NL)

14:15-15:00 Geneviève Almouzni, FR - Structure and function of dynamic chromatin organization (The EMBO Keynote Lecture)

15:00-15:30 Luciano di Croce, ES - The role of protein complexes in epigenetic reprogramming and cancer development (Invited speaker 1) 

15:30-15:45 Molly Godfrey - Dose dependent tumour suppressor and continuous essential functions of the SWI/SNF BAF complex

15:45-16:15 Stefan Legewie - Dynamics of estrogen-dependent transcription at the single-cell level (Invited speaker 13)

16:15-16:45 Break

16:45-17:15 Wouter de Laat, NL - The 3D Genome Promise: wiring non-coding genetic variation to genes.(Invited speaker 3) 

17:15-17:45 Heinrich Leonardt, DE - Role and regulation of DNA modifications during development and disease

17:45-18:00 Robin van der Weide, NL - The Mediator subunit MED12 restricts heterochromatin domain formation

18:00-18:30 Vahid Shahrezaei, GB -Mathematical and computational modelling of stochastic gene expression: the role of nuclear transport and cell size (Invited speker 4)

18:30-20:00 Welcome drinks and Finger food

19:00-19:30 Meet the speakers 

20:00-20:30 Theatre performance: Epigenetic Human Simulation, produced by Orion Maxted 

20:30-21:30 Gender & Diversity get together

Panel/ open discussion

The informal ‘Gender & Diversity get together’ is open to all participants. The meeting is designed to help address challenges that minorities face in science and to support these minorities in our science communities providing an open forum for discussion and mentoring. Invited speakers: Anne-Lise Børresen-Dale (Oslo University Hospital, NO) and Henk Stunnenberg, (Faculty of Science, Radboud Institute for Molecular Life Sciences, NL)

DAY 2: Wednesday 28 November 

Session 2: Epigenetics and clinical cancer: A systems medicine view 

Session chairs: Luca Magnani (Imperial College London, UK) and Stefan Wiemann (Deutsches Krebs-forschungs zentrum, DE)

09:00-09:45 Pamela Munster, US - Epigenetic modulation of immunotherapy

09:45-10:15 Lucia Altucci, IT - Innovative therapeutic strategies against cancer, (epi)drug discovery and development (Invited speaker 5) 

10:15-10:30 Sudipto Das, IE - Novel DNA methylation landscape of metastatic colorectal cancer reveals significant epigenetic regulation of disease-associated enhancer regions

10:30-11:00 Break

11:00-11:30 Christoph Plass, DE – DNMT and HDAC inhibitors globally induce cryptic TSSs encoded in long terminal repeats (Invited speaker 6) 

11:30-11:45 Ylenia Perone, UK - SREBP1 drives KRT80-dependent cytoskeletal changes and invasive behavior in endocrine resistant ERα breast cancer

11:45-12:15 Lodewyk Wesssels, NL - Molecular data integration for therapy response prediction (Invited speaker 7) 

12:15-12:30 Caroline Wiggers, NL - Convergence on subtle regulatory changes with subtype specific manifestation in relapsing acute myeloid leukemia

12:30-13:00 Maria Carmo-Fonseca, PT - RNA-mediated transcriptional control in stemness, oncogenesis and aging: Tailored disease treatments.(Invited speaker 8) 

13:00-13:15 Poster flashes

13:15-14:15 Lunch

13.15 - 14.15 Lunch meeting open to all conference visitors: Workshop by Illumina

Illumina Workshop: “DNA Methylation Profiling, a key player in Cancer Research”

Join us at this workshop to hear from two leading scientists using DNA Methylation profiling and learn how you, too, could benefit from its potential value in your Cancer Research.

The session will feature two presentations:

“Assessment of Global Promoter Methylation Status for Classifying Brain - and other Tumors”  

Prof. Dr. med. Andreas von Deimling. Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany

“Using DNA Methylation Profiling in Human Health and Disease”

Dr. Manel Esteller. Cancer Epigenetics and Biology Program (PEBC), Institut d'Investigació

Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain

14:15-15:45 Posters even numbers 

Session 3: Epigenetics and clinical cancer: metabolic reprogramming 

Session chairs: Hans Westerhoff (University of Amsterdam, NL) and Marco Vanoni (University of Milano-Bicocca IT)

15:45-16:00 Kathrin Thedieck, DE - Exploring the links between metabolism and epigenetics in breast cancer – MESI-STRAT and EpiPredict

16:00-16:30 Massimo Loda, US - Metabolic dependencies in prostate cancer: regulation and targeting of lipogenesis (Invited speaker 9) 

16:30-16:45 Colin Logie, NL - Integration of the glucocorticoid response in primary human monocytes using topologically associated domains and transcription through CTCF-bound sites

16:45-17:00 Rohit Bharat, IT - Glutamine mediated differential metabolic rewiring in endocrine therapy resistant and sensitive breast cancer cells

17:00-17:30 Titziana Bonaldi, IT - Proteomics and functional genomics to understand epigenetic gene regulation: Tools to elucidate the histone code (Invited speaker 10)

17:30-18:30 Drinks 

18:00-18:30 Meet the speakers

19:-00 Conference dinner - Pompstation Zeeburgerdijk 52 – Amsterdam

DAY 3: Thursday 29 November 

Session 4: Innovative epigenetic interference tools and synthetic biology

Session chairs: Marianne Rots (University Medical Centre Groningen, NL) and Antal Kiss (Biological Research Centre HU)

11:00-11:30 Toni Cathomen, DE - Therapeutic genome editing – opportunities and pitfalls (Invited speaker 16)

12:45-13:45 Lunch

13:45-15:15 Posters odd numbers 

15:15-15:45 Meet the speakers

15:45-16:15 Henk Stunnenberg, NL - Epigenetic modulation of a preserved 3D chromatin landscape in distinct states of pluripotency (Invited speaker 2) 

16:15-18:00 Drinks and bites 

16.30-18:00 Science café ‘Business Ethics Research’

Conducted by Pieter van Boheemen, Rathenau Institute, NL 

Invited speakers: Maria Rodriguez Martinez (IBM Research, CH), Lucia Altucci (Epi-C, Second University of Napels, IT), Ian Bell (Business Developer, Oncode Institute, NL) and Eline Bunnik (Erasmus Medical Center, Rotterdam)

Organized by Will Beckman, Maryam Soleimani Dodaran, Desiree Goubert & Stefania Astrologo Early Stage Researchers of  EU- H2020 EpiPredict project

“The Science café ‘Business Ethics Research’ will cover prospects and challenges for translation and commercialization of breakthroughs regarding the systems epigenetics approach. We will introduce ethical, societal, legal aspects and potential hurdles of precision medicine. 

This event will encourage a dialogue and debate involving guest speakers from industry and research within the exciting field of systems epigenetics as well as experts from social sciences and experts that act on the interchange between innovative research findings and the market. 

The Science café will be opened by a short speech given by the guest speakers, followed by a dialogue in reaction to a set of critical questions. The setting will be informal and accompanied by snacks and drinks.”

DAY 4: Friday 30 November 

Session 5: Epigenetics, cell heterogeneity and cancer stem cells driving tumour evolution

Session chairs: Stefan Wiemann (Deutsches Krebs-forschungs zentrum, DE) and Ed Curry (Imperial College London, UK)

09:00-09:15 Poster prize awarding 

09:15-10:00 Jonathan Chubb, GB - Implications of transcriptional mechanism for cell decision-making (Keynote speaker)

10:00-10:30 Luca Magnani, GB - Epigenomic maps in breast cancer to understand regulatory networks of cancer cells and determine therapy responsiveness (Invited speaker 14)

10:30-10:45 Rajendra Pangeni - Histone Methyltransferase G9A contributes to stemness and tumorigenicity by epigenome reprogramming in Non-Small Cell Lung Cancer

10:45-11:15 Break

11:15-11:45 Maria Rodriguez Martinez, CH - Unravelling tumour heterogeneity with single cell proteomics (Invited speaker 15)

11:45-12:00 Josep Monserrat, UK - The MSL acetyltransferase complex is required to limit chromosomal instability and sustain cancer cell self-renewal

12:00-12:30 Anne-Lise Børresen-Dale, NO - Epigenetics of breast cancer: Implications on progression and clinical outcome (Invited speaker 17)

12:30-13:00 Paola Scaffidi, GB - Epigenetic mechanisms of cancer cell self-renewal (Invited speaker 16)

13:00-13:15 Meeting closure